Tumor-specific changes in DNA methylation are both acquired actively through transcription-coupled processes and passively accumulated over time. Analysis across B cell malignancies now shows that these changes provide insight into the cellular origin as well as the proliferative history of tumors and thereby have diagnostic value and prognostic value, respectively.
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Strati, P., Green, M.R. A ticking clock for B cell tumors. Nat Cancer 1, 1035–1037 (2020). https://doi.org/10.1038/s43018-020-00132-1
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DOI: https://doi.org/10.1038/s43018-020-00132-1