Mitochondrial DNA damage, metabolic disruption and aging have all been associated with cancer. These three threads are now woven together to show that aging-associated somatic mutations to mitochondrial DNA alter mitochondrial serine metabolism to support cell transformation and colon-cancer development.
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Prag, H.A., Murphy, M.P. mtDNA mutations help support cancer cells. Nat Cancer 1, 941–942 (2020). https://doi.org/10.1038/s43018-020-00128-x
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DOI: https://doi.org/10.1038/s43018-020-00128-x
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