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IMMUNOTHERAPY

Pseudovirus for immunotherapy

Locally injected lipid nanoparticles that deliver RNA to elicit danger signals and simultaneously contain RNA that encodes a membrane-anchored version of the cytokine IL-12 can induce immunogenic cell death in tumors. This multipronged platform induces anticancer immune responses to the injected lesion as well as to distant tumors and hence produces an abscopal effect.

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Fig. 1: Injection of synthetic oncolytic viruses for the induction ICD.

References

  1. Hodi, F. S. et al. N. Engl. J. Med. 363, 711–723 (2010).

    Article  CAS  Google Scholar 

  2. Kepp, O., Marabelle, A., Zitvogel, L. & Kroemer, G. Nat. Rev. Clin. Oncol. 17, 49–64 (2020).

    Article  CAS  Google Scholar 

  3. Li, Y. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0095-6 (2020).

  4. Casares, N. et al. J. Exp. Med. 202, 1691–1701 (2005).

    Article  CAS  Google Scholar 

  5. Vacchelli, E. et al. Science 350, 972–978 (2015).

    Article  CAS  Google Scholar 

  6. Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Nat. Rev. Immunol. 17, 97–111 (2017).

    Article  CAS  Google Scholar 

  7. Momin, N. et al. Sci. Transl. Med. 11, eaaw2614 (2019).

    Article  Google Scholar 

  8. Ribas, A. et al. Cell 170, 1109–1119.e10 (2017).

    Article  CAS  Google Scholar 

  9. Bernards, R., Dessain, S. K. & Weinberg, R. A. Cell 47, 667–674 (1986).

    Article  CAS  Google Scholar 

  10. Ravindran, R. et al. Science 343, 313–317 (2014).

    Article  CAS  Google Scholar 

  11. Levine, B. & Kroemer, G. Cell 176, 11–42 (2019).

    Article  CAS  Google Scholar 

  12. Rodrigues, L. O. C. P., Graça, R. S. F. & Carneiro, L. A. M. Front. Immunol. 9, 1306 (2018).

    Article  Google Scholar 

  13. Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J. & Kroemer, G. Nat. Rev. Immunol. 15, 405–414 (2015).

    Article  CAS  Google Scholar 

  14. Voorwerk, L. et al. Nat. Med. 25, 920–928 (2019).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Oliver Kepp or Guido Kroemer.

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Kepp, O., Kroemer, G. Pseudovirus for immunotherapy. Nat Cancer 1, 860–861 (2020). https://doi.org/10.1038/s43018-020-00107-2

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