Locally injected lipid nanoparticles that deliver RNA to elicit danger signals and simultaneously contain RNA that encodes a membrane-anchored version of the cytokine IL-12 can induce immunogenic cell death in tumors. This multipronged platform induces anticancer immune responses to the injected lesion as well as to distant tumors and hence produces an abscopal effect.
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Kepp, O., Kroemer, G. Pseudovirus for immunotherapy. Nat Cancer 1, 860–861 (2020). https://doi.org/10.1038/s43018-020-00107-2
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DOI: https://doi.org/10.1038/s43018-020-00107-2