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L1CAM links regeneration to metastasis


Metastasis competence can be acquired early in tumorigenesis, although its underlying molecular intricacies remain unclear. A recent study provides key information about the function of L1CAM in conferring metastasis-initiation potential and chemoresistance in colorectal cancer by hijacking epithelial regenerative mechanisms.

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Fig. 1: L1CAM+ cells direct regeneration and metastasis.


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Correspondence to Gloria Pascual or Salvador A. Benitah.

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The authors declare no competing interests.

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Pascual, G., Benitah, S.A. L1CAM links regeneration to metastasis. Nat Cancer 1, 22–24 (2020).

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