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Finding cancer drivers in the UPS system

Identifying cancer driver mutations is essential to understand disease biology and devise effective therapies, but remains a complex endeavor. A focused analytical approach is now presented that defines driver mutations affecting ubiquitin-mediated proteolysis through machine learning and mining of cancer multi-omics data.

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Fig. 1: The effects of mutations in E3 ligases and degrons on the target proteins in cancer cells.


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Correspondence to Han Liang.

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The author declares no competing interests.

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Liang, H. Finding cancer drivers in the UPS system. Nat Cancer 1, 20–21 (2020).

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