Extended Data Fig. 9: Impact of HLA genetic variation on survival. | Nature Cancer

Extended Data Fig. 9: Impact of HLA genetic variation on survival.

From: Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

Extended Data Fig. 9

(a-d) Association of HLA class I haplotypes and outcome. There was no association between HLA class I haplotypes and overall survival (N=89 patients, log rank p=0.175; a). The same observations held true for HLA-B haplotypes (N=89 patients, log rank p=0.95; b). (c) There was a trend towards longer overall survival for TMB high tumors with maximal germline HLA class I heterozygosity compared to tumors with low TMB and maximal germline HLA class I homozygosity (N=31 patients, log rank p=0.096). (d) Maximal germline heterozygosity vs. homozygosity with more than one HLA loci was not associated with outcome (N=89 patients, log rank p=0.95). (e) Cases with maximal germline HLA class I heterozygosity were found to have a less clonal TCR repertoire (N=60 patients, Kruskal-Wallis p=0.01). Center values of the box plots in (e) indicate median values and error bars denote 95% confidence intervals. P values are based on two-sided testing.

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