Fig. 6: The IGF-1–IGF-1R axis is associated with resistance to anti-PD-1–PD-L1 immunotherapy in patients with lung cancer. | Nature Cancer

Fig. 6: The IGF-1–IGF-1R axis is associated with resistance to anti-PD-1–PD-L1 immunotherapy in patients with lung cancer.

From: Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade

Fig. 6

a, Plasma IGF-1 levels in anti-PD-1–PD-L1-treated patients with NSCLC with NDB (n = 27) or DCB (n = 13). b, Immunohistochemical quantification (H-score) of IGF-1R in tumors from patients with NSCLC with NDB (n = 6) or DCB (n = 7) after anti-PD-1–PD-L1 treatment. Data are expressed as means ± s.e.m. P values were calculated by two-sided Welch’s t-test. c, Representative images for IGF-1R immunostaining in four lung cancer specimens (two adenocarcinomas (AC) and two squamous cell carcinoma (SCC)). Scale bars, 50 μm. Numerical source data are provided as a source data file.

Source data

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