Intratumoral genetic heterogeneity of driver somatic mutations is present in a variety of tumor types, yet the extent of heterogeneity is variable. We propose that this variation is a reflection of the inherent biology of a given tumor type, representing the pace of metastatic dissemination and hence clinical disease course.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer
Nature Communications Open Access 22 March 2024
-
Spatial immune composition of tumor microenvironment in patients with pancreatic cancer
Cancer Immunology, Immunotherapy Open Access 08 November 2023
-
Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)
npj Precision Oncology Open Access 18 July 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Greaves, M. Cancer Discov. 5, 806–820 (2015).
Greaves, M. Nat. Rev. Cancer 7, 213–221 (2007).
Gillies, R. J., Verduzco, D. & Gatenby, R. A. Nat. Rev. Cancer 12, 487–493 (2012).
Williams, M. J. et al. Nat. Genet. 50, 895–903 (2018).
Greaves, M. & Maley, C. C. Nature 481, 306–313 (2012).
Turajlic, S. et al. Cell 173, 595–610 (2018).
Makohon-Moore, A. P. et al. Nat. Genet. 49, 358–366 (2017).
Maley, C. C. et al. Nat. Rev. Cancer 17, 605–619 (2017).
Krabbe, L.-M., Bagrodia, A., Margulis, V. & Wood, C. Semin. Intervent. Radiol. 31, 27–32 (2014).
Kleeff, J. et al. Nat. Rev. Dis. Primers 2, 16022 (2016).
Winter, J. M. et al. Ann. Surg. Oncol. 19, 169–175 (2012).
Turajlic, S. et al. Cell 173, 581–594 (2018).
McDonald, O. G. O. G. et al. Nat. Genet. 49, 367–376 (2017).
Gomez, K. et al. BMC Cancer 18, 85 (2018).
Gundem, G. et al. Nature 520, 353–357 (2015).
Kohutek, Z. A. et al. Cold Spring Harb. Mol. Case Stud. 3, a001701 (2017).
Blakely, C. M. et al. Nat. Genet. 49, 1693–1704 (2017).
Juric, D. et al. Nature 518, 240–244 (2015).
Jamal-Hanjani, M. et al. N. Engl. J. Med. 376, 2109–2121 (2017).
Kovac, M. et al. Nat. Commun. 6, 6336 (2015).
Acknowledgements
Research support by CA179991 and CA220508 to C.A.I.D., who also receives research support from Bristol-Myers Squibb. K.L. is supported by a UK Medical Research Council Skills Development Fellowship Award (grant reference number MR/P014712/1). C.S. is supported by the Francis Crick Institute that receives its core funding from Cancer Research UK (FC001169,FC001202), the UK Medical Research Council (FC001169, FC001202), and the Wellcome Trust (FC001169, FC001202) and from Cancer Research UK (TRACERx, PEACE and CRUK Cancer Immunotherapy Catalyst Network), the CRUK Lung Cancer Centre of Excellence, Stand Up 2 Cancer (SU2C), the Rosetrees Trust, NovoNordisk Foundation (ID16584) and the Breast Cancer Research Foundation (BCRF), European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ ERC grant agreement n°FP7 – 617844 (PROTEUS) and Marie Curie Network PloidyNet.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Iacobuzio-Donahue, C.A., Litchfield, K. & Swanton, C. Intratumor heterogeneity reflects clinical disease course. Nat Cancer 1, 3–6 (2020). https://doi.org/10.1038/s43018-019-0002-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43018-019-0002-1
This article is cited by
-
Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer
Nature Communications (2024)
-
Lipids as mediators of cancer progression and metastasis
Nature Cancer (2024)
-
Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)
npj Precision Oncology (2023)
-
Unraveling the Drivers of Tumorigenesis in the Context of Evolution: Theoretical Models and Bioinformatics Tools
Journal of Molecular Evolution (2023)
-
Spatial immune composition of tumor microenvironment in patients with pancreatic cancer
Cancer Immunology, Immunotherapy (2023)