Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Linking the length scales

A challenge for multiscale simulations is how to link the macroscopic and microscopic length scales effectively. A new machine-learning-based sampling approach enables full exploration of macro configurations while retaining the precision of a microscale model.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Illustration of multiscale simulations of RAS–lipid interactions.


  1. Bhatia, H. et al. Nat. Mach. Intell. (2021).

  2. Karr, J. R. et al. Cell 150, 389–401 (2012).

    Article  Google Scholar 

  3. Amaro, R. & Mulholland, A. Nat. Rev. Chem. 2, 0148 (2018).

    Article  Google Scholar 

  4. Mennucci, B. & Corni, S. Nat. Rev. Chem. 3, 315–330 (2019).

    Article  Google Scholar 

  5. Peñalba, J. V. & Wolf, J. B. W. Nat. Rev. Genet. 21, 476–492 (2020).

    Article  Google Scholar 

  6. Weinan, E. Principles of Multiscale Modeling (Cambridge Univ. Press, 2011).

  7. Alber, M. et al. npj Digit. Med. 2, 115 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Shangying Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, S., Bianco, S. Linking the length scales. Nat Mach Intell 3, 374–375 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing