The metabolic sensor enzyme OGT dynamically O-GlcNAcylates hexokinase 1 (HK1). This modification enhances the localization of HK1 to mitochondria in response to glucose flux and facilitates the formation of a glycolytic metabolon on the mitochondrial outer membrane, leading to increased rates of both glycolytic and mitochondrial ATP production.
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References
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This is a summary of: Wang, H. et al. Organization of a functional glycolytic metabolon on mitochondria for metabolic efficiency. Nat. Metab. https://doi.org/10.1038/s42255-024-01121-9 (2024).
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O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production. Nat Metab 6, 1655–1656 (2024). https://doi.org/10.1038/s42255-024-01120-w
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DOI: https://doi.org/10.1038/s42255-024-01120-w
