Pancreatic β-cells do not appear to require interactions with neighbouring non-β-cells (α-cells, δ-cells and γ-cells) to regulate insulin secretion. These results are clinically relevant and support the development of treatments for diabetes that involve the generation of β-like cells alone, whether from pluripotent cells or by in situ conversion of non-β-cells.
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References
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This is a summary of: Perez-Frances, M. et al. Regulated and adaptive in vivo insulin secretion from islets only containing β-cells. Nat. Metab. https://doi.org/10.1038/s42255-024-01114-8 (2024).
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Regulated insulin secretion from human and mouse islets exclusively composed of β-cells. Nat Metab 6, 1659–1660 (2024). https://doi.org/10.1038/s42255-024-01117-5
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DOI: https://doi.org/10.1038/s42255-024-01117-5
