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Cancer metabolism

Affinity war: PSAT1 outcompetes the rest

Nature Metabolism volume 6, pages 1429–1430 (2024)Cite this article

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Resistance to glutamine restriction is mediated by increased serine synthesis. The high affinity of serine synthesis enzyme PSAT1 for glutamate drives sustained glutamine utilization. Combined pathway targeting limits tumour growth in mouse breast cancer models.

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Fig. 1: PSAT1 high affinity drives TCA cycle anaplerosis under glutaminase inhibition.

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Authors and Affiliations

  1. Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA

    Richard Possemato

  2. Laura & Isaac Perlmutter Cancer Center, New York, NY, USA

    Richard Possemato

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  1. Richard Possemato
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Correspondence to Richard Possemato.

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Competing interests

R.P. holds equity in Raze Therapeutics, which holds patents on PHGDH inhibitors.

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Possemato, R. Affinity war: PSAT1 outcompetes the rest. Nat Metab 6, 1429–1430 (2024). https://doi.org/10.1038/s42255-024-01096-7

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