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Microglial metabolism

Complex roles for mitochondrial complexes in microglia

Nature Metabolism volume 6, pages 1426–1428 (2024)Cite this article

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Metabolism impacts various cellular types, and microglia are no exception. Two recent studies in Nature Metabolism demonstrate that impairing the mitochondrial respiratory chain, via deficiencies in complex I or complex III, affects microglia in a highly context-dependent manner.

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Fig. 1: Widespread consequences of complex I and complex III deficiency in microglia.

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland

    Rosa C. Paolicelli

  2. Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK

    Stefano Pluchino

Authors
  1. Rosa C. Paolicelli
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  2. Stefano Pluchino
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Corresponding authors

Correspondence to Rosa C. Paolicelli or Stefano Pluchino.

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Competing interests

S.P. is founder, CSO and shareholder (>5%) of CITC Ltd.

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Paolicelli, R.C., Pluchino, S. Complex roles for mitochondrial complexes in microglia. Nat Metab 6, 1426–1428 (2024). https://doi.org/10.1038/s42255-024-01095-8

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