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Alcohol metabolism

Gut–liver highway of ALDH2 in drinking

Nature Metabolism volume 6, pages 1202–1203 (2024)Cite this article

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In this issue of Nature Metabolism, Fu et al. show that genetic deletion of aldehyde dehydrogenase 2 (ALDH2) simultaneously in the gut and liver synergistically regulates acetaldehyde (AcH) levels and alcohol consumption.

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Fig. 1: Hypothetical model showing possible mechanisms for the gut–liver ALDH2 axis in alcohol drinking behaviours.

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Acknowledgements

This study is supported by NIH-NIAAA grants (UO1AA019971, U24AA024605, and P50AA022538) and by the VA Merit (I01 BX004517) and Senior Research Career Scientist award (IK6BX00603) to S.C.P. and T32 AA026577 to E.M‥

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Authors and Affiliations

  1. Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA

    Subhash C. Pandey & Emir Malovic

  2. Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA

    Subhash C. Pandey

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  1. Subhash C. Pandey
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  2. Emir Malovic
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Contributions

S.C.P. wrote the first draft that was further edited and finalized by S.C.P. and E.M. Both authors approved the final version of the article.

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Correspondence to Subhash C. Pandey.

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The authors declare no competing interests.

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Pandey, S.C., Malovic, E. Gut–liver highway of ALDH2 in drinking. Nat Metab 6, 1202–1203 (2024). https://doi.org/10.1038/s42255-024-01071-2

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