In an attempt to investigate the role of enteroendocrine cells in the colon using elegant, targeted depletion tools, the authors of a study published in this issue of Nature Metabolism highlight the orexigenic role of a bacterial metabolite in the intestinal lumen, l-glutamate.
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Le Dréan, G., Blottière, H.M. Glutamate from the microbiome controls host metabolism. Nat Metab 6, 987–989 (2024). https://doi.org/10.1038/s42255-024-01050-7
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DOI: https://doi.org/10.1038/s42255-024-01050-7
