Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolic disease

Macrophage vesicles in antidiabetic drug action

Nature Metabolism volume 6, pages 785–786 (2024)Cite this article

Subjects

Thiazolidinediones (TZDs) are potent insulin-sensitizing drugs, but their use is accompanied by adverse side-effects. Rohm et al. now report that TZD-stimulated macrophages release miR-690-containing vesicles that improve insulin sensitization and bypass unwanted side-effects.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: TZDs induce the production of insulin-sensitizing extracellular vesicles by macrophages.

References

  1. Blüher, M. Nat. Rev. Endocrinol. 15, 288–298 (2019).

    Article  PubMed  Google Scholar 

  2. Johnson, A. M. & Olefsky, J. M. Cell 152, 673–684 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. Freeman, D. W. et al. Diabetes 67, 2377–2388 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kranendonk, M. E. et al. Obesity 22, 1296–1308 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Kulaj, K. et al. Nat. Commun. 14, 709 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Blandin, A. et al. Cell Rep. 42, 112866 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Ying, W. et al. Cell 171, 372–384.e12 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Hernandez-Quiles, M., Broekema, M. F. & Kalkhoven, E. Front. Endocrinol. 12, 624112 (2021).

    Article  Google Scholar 

  9. Stienstra, R. et al. J. Biol. Chem. 283, 22620–22627 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. Cariou, B., Charbonnel, B. & Staels, B. Trends Endocrinol. Metab. 23, 205–215 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Ahmadian, M. et al. Nat. Med. 19, 557–566 (2013).

    Article  CAS  PubMed  Google Scholar 

  12. Rohm, T. V. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01023-w (2024).

    Article  PubMed  Google Scholar 

  13. Ying, W. et al. Cell Metab. 33, 781–790.e5 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Gao, H. et al. Cell Metab. 34, 978–990.e4 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Li, Z., Wang, Y., Li, S. & Li, Y. Front. Endocrinol. 12, 680328 (2021).

    Article  Google Scholar 

Download references

Acknowledgements

We acknowledge funding from ZonMw and the Dutch Diabetes Research Foundation to R.S. and from the Netherlands Organisation for Health Research and Development (ZonMw) programme for translational research, and Diabetes Fonds (project number 95105007) to E.K.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands

    Rinke Stienstra

  2. Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands

    Rinke Stienstra

  3. Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

    Eric Kalkhoven

Authors
  1. Rinke Stienstra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric Kalkhoven
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric Kalkhoven.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stienstra, R., Kalkhoven, E. Macrophage vesicles in antidiabetic drug action. Nat Metab 6, 785–786 (2024). https://doi.org/10.1038/s42255-024-01030-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-024-01030-x

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing