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Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism

Nature Metabolism volume 6, pages 205–206 (2024)Cite this article

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Glycerol-3-Phosphate (G3P) and phosphoethanolamine (pEtN) biosynthetic pathways are modulated during senescence establishment to sustain lipid droplet accumulation and senescence-associated secretome. These findings reveal new targets for an immunomodulatory approach against senescent cells.

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Fig. 1: G3P and pEtN are part of a senescence-associated metabolic signature.

References

  1. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997). This paper reports for the first time, to our knowledge, that oncogenic activation triggers senescence.

    Article  CAS  PubMed  Google Scholar 

  2. Di Micco, R., Krizhanovsky, V., Baker, D. & d'Adda di Fagagna, F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021). A review article that discusses the modulators of senescence establishment and its involvement in several age-related disorders.

    Article  PubMed  Google Scholar 

  3. Wiley, C. D. & Campisi, J. The metabolic roots of senescence: mechanisms and opportunities for intervention. Nat. Metab. 3, 1290–1301 (2001). A review article that thoroughly describes several metabolic adaptations in senescence, including lipid droplet accumulation.

    Article  Google Scholar 

  4. Orozco, J. M. et al. Dihydroxyacetone phosphate signals glucose availability to mTORC1. Nat. Metab. 2, 893–901 (2020). This paper shows that DHAP, a precursor of G3P, is sensed by mTORC1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Tighanimine, K. et al. A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism. Nat. Metab. https://doi.org/10.1038/s42255-023-00972-y (2024).

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Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism. Nat Metab 6, 205–206 (2024). https://doi.org/10.1038/s42255-024-00975-3

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