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Gastroenterology

Proline fuels ILC3s to maintain gut health

Nature Metabolism volume 5, pages 1848–1849 (2023)Cite this article

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Group 3 innate lymphoid cells (ILC3s) maintain intestinal barrier integrity and nutrient absorption via IL-22; however, little is known about how these immune cells fuel effector function. Wu et al. now report that uptake of dietary proline acts as a critical metabolic modulator of the ILC3 transcriptome and cytokine production to maintain gut health.

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Fig. 1: Dietary proline regulates ILC3 responses to prevent intestinal inflammation.

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Acknowledgements

M.R.H. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 105644/Z/14/Z), a BBSRC responsive mode grant (BB/T014482/1) and a Lister Institute of Preventative Medicine Prize.

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Authors and Affiliations

  1. Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK

    Matthew R. Hepworth

  2. Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

    Matthew R. Hepworth

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Correspondence to Matthew R. Hepworth.

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Hepworth, M.R. Proline fuels ILC3s to maintain gut health. Nat Metab 5, 1848–1849 (2023). https://doi.org/10.1038/s42255-023-00895-8

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