Okreglak et al. explore the molecular mechanisms that link organellar pH dynamics with the cell cycle, and find that vacuolar pH oscillates during cell cycle phases to ensure an adequate supply of amino acids during cell division. This study offers metabolic insight into the fundamental mechanisms that couple amino acid availability to the cell cycle through pH fluctuations.
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The author declares no competing interests.
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Kane, P.M. A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle. Nat Metab 5, 1652–1653 (2023). https://doi.org/10.1038/s42255-023-00875-y