Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Inhibition of the serotonin transporter induces dysfunction of human brown adipose tissue

By using a combination of transcriptomics, primary adipocyte culture and experimental medicine approaches, we identified the sodium-dependent serotonin transporter SERT as a novel regulator of human brown adipose tissue function.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Sertraline suppresses 18F-FDG uptake by BAT.


  1. McNeill, B. T. et al. Human brown adipose tissue as a therapeutic target: warming up or cooling down? Eur. J. Endocrinol. 184, 243–259 (2021). A Review article that discusses the potential of activating BAT as a therapeutic strategy.

    Article  Google Scholar 

  2. Becher, T. et al. Brown adipose tissue is associated with cardiometabolic health. Nat. Med. 27, 58–65 (2021). This paper reports that individuals with detectable glucose uptake by BAT at room temperature are protected from cardiometabolic disease.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Blondin, D. P. et al. Human brown adipocyte thermogenesis is driven by beta2-AR stimulation. Cell Metab. 32, 287–300 (2020). This paper reports that different adrenoreceptors regulate human and rodent BAT thermogenesis.

    Article  CAS  PubMed  Google Scholar 

  4. Crane, J. D. et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat. Med. 21, 166–172 (2015). This paper demonstrates that reduced circulating peripheral serotonin increases BAT thermogenesis and protects against metabolic dysfunction in mice.

    Article  CAS  PubMed  Google Scholar 

  5. Luo, Y. et al. National prescribing patterns of antidepressants in the treatment of adults with major depression in the US between 1996 and 2015. Front. Psych. 11, 35 (2020). This paper demonstrates that SSRIs have been the most prescribed class of antidepressants over the past 20 years.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Suchacki, K. J. et al. The serotonin transporter sustains human brown adipose tissue thermogenesis. Nat. Metab. (2023).

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Inhibition of the serotonin transporter induces dysfunction of human brown adipose tissue. Nat Metab 5, 1264–1265 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing