By using a combination of transcriptomics, primary adipocyte culture and experimental medicine approaches, we identified the sodium-dependent serotonin transporter SERT as a novel regulator of human brown adipose tissue function.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
McNeill, B. T. et al. Human brown adipose tissue as a therapeutic target: warming up or cooling down? Eur. J. Endocrinol. 184, 243–259 (2021). A Review article that discusses the potential of activating BAT as a therapeutic strategy.
Becher, T. et al. Brown adipose tissue is associated with cardiometabolic health. Nat. Med. 27, 58–65 (2021). This paper reports that individuals with detectable glucose uptake by BAT at room temperature are protected from cardiometabolic disease.
Blondin, D. P. et al. Human brown adipocyte thermogenesis is driven by beta2-AR stimulation. Cell Metab. 32, 287–300 (2020). This paper reports that different adrenoreceptors regulate human and rodent BAT thermogenesis.
Crane, J. D. et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat. Med. 21, 166–172 (2015). This paper demonstrates that reduced circulating peripheral serotonin increases BAT thermogenesis and protects against metabolic dysfunction in mice.
Luo, Y. et al. National prescribing patterns of antidepressants in the treatment of adults with major depression in the US between 1996 and 2015. Front. Psych. 11, 35 (2020). This paper demonstrates that SSRIs have been the most prescribed class of antidepressants over the past 20 years.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Suchacki, K. J. et al. The serotonin transporter sustains human brown adipose tissue thermogenesis. Nat. Metab. https://doi.org/10.1038/s42255-023-00839-2 (2023).
Rights and permissions
About this article
Cite this article
Inhibition of the serotonin transporter induces dysfunction of human brown adipose tissue. Nat Metab 5, 1264–1265 (2023). https://doi.org/10.1038/s42255-023-00851-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-023-00851-6
