Sa et al. identified a distinct neuronal subpopulation that controls brown adipose tissue thermogenesis. In mice fed a high-fat diet, hypothalamic GABRA5 neurons are deactivated by GABA released by surrounding astrocytes and inhibition of GABA synthesis ameliorates diet-induced obesity.
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We thank C. Holleman (Helmholtz Munich; Germany) for her comments. The research of the authors is supported by funding from the European Research Council (ERC) (C.G.-C.: STG grant AstroNeuroCrosstalk no. 757393), the German Research Foundation (DFG) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198), and Helmholtz Association - Initiative and Networking Fund. I.G.-G. is supported by a Ramón y Cajal Award (RYC2021-031225-I) from the Ministerio de Ciencia e Innovación of Spain. The funders had no role in decision to publish or prepare this work.
The authors declare no competing interests.
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González-García, I., García-Cáceres, C. Astrocytic GABA in LHA is an obesity ‘thermostat’. Nat Metab 5, 1454–1455 (2023). https://doi.org/10.1038/s42255-023-00849-0