This study shows that a 10% weight loss induced by calorie restriction and multimodal exercise training results in a much greater increase in whole-body insulin sensitivity than matched weight loss induced by calorie restriction alone. This result underscores the importance of adding regular exercise to a weight loss programme, as it improves metabolic health.
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References
Klein, S., Wadden, T. & Sugerman, H. J. AGA technical review on obesity. Gastroenterology 123, 882–932 (2002). This review summarizes the alterations in metabolic function and the medical comorbidities associated with obesity.
Jensen, M. D. et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the Obesity Society. J. Am. Coll. Cardiol. 63, 2985–3023 (2014). This paper provides guidelines for the clinical management of obesity.
Magkos, F. et al. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metab. 23, 591–601 (2016). This paper reports the effects of progressive amounts of diet-induced weight loss on multi-organ insulin sensitivity.
Perseghin, G. et al. Increased glucose transport–phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N. Engl. J. Med. 335, 1357–1362 (1996). This paper reports the effects of exercise on whole-body insulin sensitivity.
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This is a summary of: Beals, J. W. et al. Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes. Nat. Metab. https://doi.org/10.1038/s42255-023-00829-4 (2023).
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Exercise increases the metabolic benefits of weight loss. Nat Metab 5, 1084–1085 (2023). https://doi.org/10.1038/s42255-023-00842-7
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DOI: https://doi.org/10.1038/s42255-023-00842-7
