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Neuroinflammation

TCA cycle deficiency in multiple sclerosis

Nature Metabolism volume 5, pages 1258–1259 (2023)Cite this article

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Impaired tricarboxylic acid cycle and oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation and contribute to axonal degeneration in multiple sclerosis.

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Fig. 1: Mitochondrial defects in acute lesions of neurons.

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Authors and Affiliations

  1. Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, Bonn, Germany

    Swadha Mishra, Fabian den Brave & Thomas Becker

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  1. Swadha Mishra
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  2. Fabian den Brave
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  3. Thomas Becker
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Correspondence to Thomas Becker.

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The authors declare no competing interests.

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Mishra, S., den Brave, F. & Becker, T. TCA cycle deficiency in multiple sclerosis. Nat Metab 5, 1258–1259 (2023). https://doi.org/10.1038/s42255-023-00840-9

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