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Systemic metabolism

Hypometabolism with the speed of ultrasound

How mammals enter hypometabolic states, known as torpor and hibernation, has fascinated researchers for decades, but the central control mechanisms that regulate entry into torpor have surfaced only recently. Yang and colleagues demonstrate that torpor-like hypometabolic states can be induced non-invasively by ultrasound, providing new routes for exploiting the underlying mechanisms and biomedical applications of this process in the future.

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Fig. 1: Ultrasound induces torpor-like hypometabolism and hypothermia.


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M.J. is supported by the Swedish Research Council (2022-03136) and the Novo Nordisk Research Foundation (grant number 0059646).

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Correspondence to Martin Jastroch.

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Jastroch, M., van Breukelen, F. Hypometabolism with the speed of ultrasound. Nat Metab 5, 722–723 (2023).

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