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Reply to: revisiting the role of serine metabolism in hepatic lipogenesis

The Original Article was published on 11 May 2023

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Fig. 1: De novo lipogenesis flux in hepatic G6PD-knockout model (control = G6PDfl/fl; hepatic ∆G6PD = Alb-Cre+ G6PDfl/fl).

Data availability

Raw data/Source data are provided with this paper.

Code availability

El-MAVEN v.12 and natural abundance correction software AccuCor are available online on GitHub ( and


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Authors and Affiliations



Z.Z., T.T. and J.R. wrote the manuscript. This work was funded by the Allen Foundation and by Ludwig Cancer Research.

Corresponding author

Correspondence to Joshua D. Rabinowitz.

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Competing interests

J.R. is a consultant and received research funding from Pfizer and is an adviser and stock owner in Colorado Research Partners, L.E.A.F. Pharmaceuticals, Rafael Pharmaceuticals, Barer Institute and its subsidiaries, Serien Therapeutics, Empress Therapeutics, and Agios Pharmaceuticals. J.R. is co-inventor of SHIN2 and related SHMT inhibitors, which have been patented by Princeton University. The remaining authors declare no competing interests.

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Zhang, Z., TeSlaa, T. & Rabinowitz, J.D. Reply to: revisiting the role of serine metabolism in hepatic lipogenesis. Nat Metab 5, 762–764 (2023).

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