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Diabetes

Zooming into process-specific risk

Nature Metabolism volume 5, pages 730–731 (2023)Cite this article

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Functional genomic analyses reveal a complex relationship between the COBLL1 gene and metabolic health, as well as how the same variant can both reduce body fat and increase the risk of type 2 diabetes.

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Fig. 1: The 2q24.3 locus is the top genetic association with lipodystrophy-like T2D, showing pleiotropic associations with increased risk of T2D but lower body-mass index and other fat-related measures.

References

  1. Deutsch, A. J., Ahlqvist, E. & Udler, M. S. Diabetologia 65, 1758–1769 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kim, H. et al. Diabetologia 66, 495–507 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Udler, M. S. et al. PLoS Med. 15, e1002654 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gómez-Ambrosi, J. et al. Int. J. Obes. 36, 286–294 (2012).

    Article  Google Scholar 

  5. Glunk, V. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00807-w (2023).

    Article  Google Scholar 

  6. Laber, S. et al. Preprint at https://doi.org/10.1101/2021.07.17.452050 (2021).

  7. Maurano, M. T. et al. Science 337, 1190–1195 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Claussnitzer, M. et al. N. Engl. J. Med. 373, 895–907 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Miguel-Escalada, I. et al. Nat. Genet. 51, 1137–1148 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Grubert, F. et al. Cell 162, 1051–1065 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Lotta, L. A. et al. Nat. Genet. 49, 17–26 (2017).

    Article  CAS  PubMed  Google Scholar 

  12. Burgess, D. J. Nat. Rev. Genet. 23, 261 (2022).

    Article  CAS  PubMed  Google Scholar 

  13. Wakeling, M. N. et al. Nat. Genet. 54, 1615–1620 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. de Goede, O. M. et al. Cell 184, 2633–2648 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bäckdahl, J. et al. Cell Metab. 33, 1869–1882 (2021).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

I.C. is recipient of a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (224662/Z/21/Z) and a research grant by the Royal Society (RGS\R1\221086). The authors are also supported by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre.

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  1. Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

    Hannah Maude & Inês Cebola

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  1. Hannah Maude
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  2. Inês Cebola
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Correspondence to Inês Cebola.

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Competing interests

I.C.’s partner holds stock options in Ochre Bio. H.M. has no competing interests to declare.

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Maude, H., Cebola, I. Zooming into process-specific risk. Nat Metab 5, 730–731 (2023). https://doi.org/10.1038/s42255-023-00770-6

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