Diabetic kidney disease is influenced by a combination of genetic and environmental factors. A study identifies risk variants in the XOR promoter that elevate its own activity in response to hyperglycaemia, which has a causative role in the onset and progression of diabetic kidney disease.
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Zhu, K., Reiser, J. XOR risk variants drive diabetic kidney disease. Nat Metab 5, 536–537 (2023). https://doi.org/10.1038/s42255-023-00768-0