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Cellular metabolism

Cholesterol drives inflammatory senescence

Nature Metabolism volume 5, pages 355–356 (2023)Cite this article

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Both cell cycle arrest and secretions of senescent cells are subject to metabolic control. In this issue of Nature Metabolism, Roh et al. show that lysosomal partitioning of cholesterol potentiates inflammatory secretion during senescence.

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Fig. 1: Cholesterol partitioning controls senescence phenotypes.

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Authors and Affiliations

  1. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Chisaka Kuehnemann & Christopher D. Wiley

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  1. Chisaka Kuehnemann
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  2. Christopher D. Wiley
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Correspondence to Christopher D. Wiley.

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Competing interests

C.W. is an inventor on a patent application by Tufts University involving lipid and sterol metabolism as a mechanism for senescent cell elimination (US Application 63/264,510 T002531 US.PRO). C.K. declares no competing interests.

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Kuehnemann, C., Wiley, C.D. Cholesterol drives inflammatory senescence. Nat Metab 5, 355–356 (2023). https://doi.org/10.1038/s42255-023-00758-2

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