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Cellular metabolism

Cholesterol drives inflammatory senescence

Both cell cycle arrest and secretions of senescent cells are subject to metabolic control. In this issue of Nature Metabolism, Roh et al. show that lysosomal partitioning of cholesterol potentiates inflammatory secretion during senescence.

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Fig. 1: Cholesterol partitioning controls senescence phenotypes.

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Correspondence to Christopher D. Wiley.

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Competing interests

C.W. is an inventor on a patent application by Tufts University involving lipid and sterol metabolism as a mechanism for senescent cell elimination (US Application 63/264,510 T002531 US.PRO). C.K. declares no competing interests.

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Kuehnemann, C., Wiley, C.D. Cholesterol drives inflammatory senescence. Nat Metab 5, 355–356 (2023). https://doi.org/10.1038/s42255-023-00758-2

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