Dai and colleagues show that activation of AMPK by glucose starvation leads to phosphorylation of GATOR2 and affects nutrient-dependent activation of mTORC1.
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A.E. laboratory acknowledges funding by a RETOS Projects Program of the Spanish Ministry of Science, Innovation and Universities, the Spanish State Research Agency (AEI/10.13039 /501100011033) co-funded by the European Regional Development Fund (PID2019-104012RB-I00), a FERO Grant for Research in Oncology and the LaCaixa Banking Foundation (LCF/PR/HR21/0046). A.E. is an EMBO Young Investigator.
The authors declare no competing interests.
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Deleyto-Seldas, N., Efeyan, A. AMPK knocks at the gate of GATOR. Nat Metab 5, 197–198 (2023). https://doi.org/10.1038/s42255-022-00729-z