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Mechanisms of disease

Anaplerosis in action

Investigation of multi-omic changes and their effects on regulation of metabolic pathways confirm anaplerotic deficiencies in methylmalonic acidaemia, strengthening the need for future therapies aimed at replenishing intermediates of the tricarboxylic acid cycle.

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Fig. 1: Dysregulation of anaplerosis and the TCA cycle in MMA.


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Correspondence to Charles P. Venditti.

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Head, P.E., Venditti, C.P. Anaplerosis in action. Nat Metab 5, 5–7 (2023).

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