Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.
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Du, Y. et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat. Med. 28, 272–282 (2022). This paper reports the generation of pancreatic islet tissues from human PSCs.
Shapiro, A. M. J. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230–238 (2000). This paper reports the Edmonton protocol for islet transplantation through the portal vein.
Shapiro, A. M. J., Pokrywczynska, M. & Ricordi, C. Clinical pancreatic islet transplantation. Nat. Rev. Endocrinol. 13, 268–277 (2017). This review article presents an overview and the challenges of clinical islet transplantation.
Guan, J. et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605, 325–331 (2022). This paper reports the chemical induction of CiPSCs by chemical reprogramming.
Liu, H. et al. Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts. Cell Stem Cell 3, 587–590 (2008). This paper reports the generation of monkey induced PSCs.
Shi, Y. et al. Inducing embryonic stem cells to differentiate into pancreatic β cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 23, 656–662 (2005). This paper reports the generation of insulin-producing cells from mouse embryonic stem cells.
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This is a summary of: Liang, Z. et al. Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets. Nat. Metab. https://doi.org/10.1038/s42255-022-00713-7 (2023).
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Abdominal transplantation of pancreatic islets to protect against type 1 diabetes. Nat Metab 5, 19–20 (2023). https://doi.org/10.1038/s42255-022-00714-6