Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.
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References
Du, Y. et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat. Med. 28, 272–282 (2022). This paper reports the generation of pancreatic islet tissues from human PSCs.
Shapiro, A. M. J. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230–238 (2000). This paper reports the Edmonton protocol for islet transplantation through the portal vein.
Shapiro, A. M. J., Pokrywczynska, M. & Ricordi, C. Clinical pancreatic islet transplantation. Nat. Rev. Endocrinol. 13, 268–277 (2017). This review article presents an overview and the challenges of clinical islet transplantation.
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This is a summary of: Liang, Z. et al. Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets. Nat. Metab. https://doi.org/10.1038/s42255-022-00713-7 (2023).
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Abdominal transplantation of pancreatic islets to protect against type 1 diabetes. Nat Metab 5, 19–20 (2023). https://doi.org/10.1038/s42255-022-00714-6
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DOI: https://doi.org/10.1038/s42255-022-00714-6
