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Gut microbiome

A high-protein diet prevents weight regain

Nature Metabolism volume 4, pages 1616–1617 (2022)Cite this article

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Sustained weight loss and weight maintenance are key challenges for the treatment of obesity. Here, the authors show that a high-protein diet following weight loss can protect against weight regain, through a process dependent on the gut microbiome.

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Fig. 1: A high-protein diet protects from weight regain through changes in the gut microbiome.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  2. VA Health Sciences San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  3. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  4. Institute of Diabetes and Metabolic Health, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

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  1. Amir Zarrinpar
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Correspondence to Amir Zarrinpar.

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Competing interests

A.Z. is a cofounder of, and equity holder in, Endure Biotherapeutics.

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Zarrinpar, A. A high-protein diet prevents weight regain. Nat Metab 4, 1616–1617 (2022). https://doi.org/10.1038/s42255-022-00699-2

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