Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Gut microbiome

A high-protein diet prevents weight regain

Nature Metabolism volume 4, pages 1616–1617 (2022)Cite this article

Subjects

Sustained weight loss and weight maintenance are key challenges for the treatment of obesity. Here, the authors show that a high-protein diet following weight loss can protect against weight regain, through a process dependent on the gut microbiome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A high-protein diet protects from weight regain through changes in the gut microbiome.

References

  1. Aronne, L. J. et al. Obesity 29, S9–S24 (2021).

    Article  Google Scholar 

  2. Fothergill, E. et al. Obesity 24, 1612–1619 (2016).

    Article  Google Scholar 

  3. Zhong, W. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00687-6 (2022).

    Article  Google Scholar 

  4. Sacks, F. M. et al. N. Engl. J. Med. 360, 859–873 (2009).

    Article  CAS  Google Scholar 

  5. Frankwich, K. A. et al. Clinical Gastroenterol. Hepatol. 13, 1625–1632 (2015).

    Article  Google Scholar 

  6. Gardner, C. D. et al. J. Am. Med. Assoc. 319, 667–679 (2018).

    Article  CAS  Google Scholar 

  7. Zarrinpar, A., Chaix, A., Yooseph, S. & Panda, S. Cell Metab. 20, 1006–1017 (2014).

    Article  CAS  Google Scholar 

  8. Dantas Machado, A. C. et al. Cell Rep. 40, 111008 (2022).

    Article  CAS  Google Scholar 

  9. Russell, B. J. et al. Cell 185, 3263–3277 (2022).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  2. VA Health Sciences San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  3. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

  4. Institute of Diabetes and Metabolic Health, University of California, San Diego, La Jolla, CA, USA

    Amir Zarrinpar

Authors
  1. Amir Zarrinpar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Amir Zarrinpar.

Ethics declarations

Competing interests

A.Z. is a cofounder of, and equity holder in, Endure Biotherapeutics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zarrinpar, A. A high-protein diet prevents weight regain. Nat Metab 4, 1616–1617 (2022). https://doi.org/10.1038/s42255-022-00699-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-022-00699-2

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing