Sustained weight loss and weight maintenance are key challenges for the treatment of obesity. Here, the authors show that a high-protein diet following weight loss can protect against weight regain, through a process dependent on the gut microbiome.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Aronne, L. J. et al. Obesity 29, S9–S24 (2021).
Fothergill, E. et al. Obesity 24, 1612–1619 (2016).
Zhong, W. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00687-6 (2022).
Sacks, F. M. et al. N. Engl. J. Med. 360, 859–873 (2009).
Frankwich, K. A. et al. Clinical Gastroenterol. Hepatol. 13, 1625–1632 (2015).
Gardner, C. D. et al. J. Am. Med. Assoc. 319, 667–679 (2018).
Zarrinpar, A., Chaix, A., Yooseph, S. & Panda, S. Cell Metab. 20, 1006–1017 (2014).
Dantas Machado, A. C. et al. Cell Rep. 40, 111008 (2022).
Russell, B. J. et al. Cell 185, 3263–3277 (2022).
A.Z. is a cofounder of, and equity holder in, Endure Biotherapeutics.
Rights and permissions
About this article
Cite this article
Zarrinpar, A. A high-protein diet prevents weight regain. Nat Metab 4, 1616–1617 (2022). https://doi.org/10.1038/s42255-022-00699-2