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Suppression of CD8+ T cells by the metabolite itaconate

The immune-modulatory metabolite itaconate is secreted by myeloid-derived suppressor cells and taken up by CD8+ T cells to suppress their proliferation and function. In mice, blocking itaconate production enhances the efficacy of immune checkpoint blockade.

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Fig. 1: Immunofluorescence analysis of human melanoma tumours revealed IRG1 co-staining with the myeloid-derived suppressor cell (MDSC) marker LOX1.

References

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This is a summary of: Zhao, H. et al. Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth. Nat. Metab. https://doi.org/10.1038/s42255-022-00676-9 (2022).

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Suppression of CD8+ T cells by the metabolite itaconate. Nat Metab 4, 1626–1627 (2022). https://doi.org/10.1038/s42255-022-00694-7

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