The human gut microbiome metabolizes hundreds of drugs, but the clinical relevance of these biotransformations remains unclear. Chen and colleagues show that gut bacterial nicotine metabolism protects against liver disease.
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References
Lindell, G. et al. Scand. J. Gastroenterol. 28, 487–494 (1993).
Chen, B. et al. Nature https://doi.org/10.1038/s41586-022-05299-4 (2022).
Whirl-Carrillo, M. et al. Clin. Pharmacol. Ther. 110, 563–572 (2021).
Lam, K. N., Alexander, M. & Turnbaugh, P. J. Cell Host Microbe 26, 22–34 (2019).
Fu, Z. D., Selwyn, F. P., Cui, J. Y. & Klaassen, C. D. Drug Metab. Dispos. 45, 1225–1238 (2017).
Huang, Y. J. et al. J. Clin. Microbiol. 52, 2813–2823 (2014).
Wada, E. & Yamasaki, K. Science 117, 152–153 (1953).
Jung, H.-S. et al. Am. J. Gastroenterol. 114, 453–463 (2019).
Benowitz, N. L. N. Engl. J. Med. 362, 2295–2303 (2010).
Benowitz, N. L. & Burbank, A. D. Trends Cardiovasc. Med. 26, 515–523 (2016).
Kalininskiy, A. et al. Lancet Respir. Med. 7, 1017–1026 (2019).
Duke, D. et al. Nat. Hum. Behav. 6, 183–192 (2022).
Carmody, R. N. et al. Nat. Microbiol. 4, 2052–2063 (2019).
Acknowledgements
This work was supported by the National Institutes of Health (R01DK114034; R01HL122593; T32HL007185).
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P.J.T. is on the scientific advisory board for Pendulum, Seed and SNIPRbiome; there is no direct overlap between the current study and these consulting duties. V.U. has no relevant declarations.
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Upadhyay, V., Turnbaugh, P.J. nicX-ing bad habits with your microbial friends. Nat Metab 4, 1442–1443 (2022). https://doi.org/10.1038/s42255-022-00684-9
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DOI: https://doi.org/10.1038/s42255-022-00684-9