The core metabolic pathways are tightly intertwined, creating challenges for metabolic engineering. Yu et al. present a synthetic decarboxylation cycle that substitutes the TCA cycle in energy metabolism, gaining high yields in the production of reduced compounds such as fatty acids.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tan, E. C. D. & Lamers, P. Front. Sustain. 2, 701509 (2021).
Becker, J., Lange, A., Fabarius, J. & Wittmann, C. Curr. Opin. Biotechnol. 36, 168–175 (2015).
Nielsen, J. & Keasling, J. D. Cell 164, 1185–1197 (2016).
Alam, M. T. et al. Nat. Commun. 8, 16018 (2017).
Park, J. O. et al. Nat. Metab. 1, 643–651 (2019).
Bakker, B. M., Overkamp, K. M., Kötter, P., Luttik, M. A. & Pronk, J. T. FEMS Microbiol. Rev. 25, 15–37 (2001).
Stincone, A. et al. Biol. Rev. Camb. Philos. Soc. 90, 927–963 (2015).
Yu, T. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00654-1 (2022).
Bogorad, I. W., Lin, T. S. & Liao, J. C. Nature 502, 693–697 (2013).
Liu, Y. et al. Cell 184, 1636–1647 (2021).
Runguphan, W. & Keasling, J. D. Metab. Eng. 21, 103–113 (2014).
Erb, T. J., Jones, P. R. & Bar-Even, A. Curr. Opin. Chem. Biol. 37, 56–62 (2017).
Orsi, E., Claassens, N. J., Nikel, P. I. & Lindner, S. N. Biotechnol. Adv. 60, 108035 (2022).
Acknowledgements
S.N.L. and M.R. are supported by Charité Universitätsmedizin Berlin.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lindner, S.N., Ralser, M. Synthetic metabolism without the TCA cycle. Nat Metab 4, 1438–1439 (2022). https://doi.org/10.1038/s42255-022-00668-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-022-00668-9