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Adipose tissue biology

Iron at the intersection of macrophage–adipocyte interactions

Nature Metabolism volume 4, pages 1434–1435 (2022)Cite this article

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Scherer and colleagues demonstrate that manipulation of iron concentrations in the mitochondrial matrix of macrophages has profound effects on their polarization, leading to concomitant changes in adipocyte iron concentrations and, ultimately, systemic metabolic effects.

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Fig. 1: Iron is part of the macrophage–adipocyte paracrine loop.

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Acknowledgements

A.H.H. is supported the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. DK121520) and by a Career Scientist Award from the Veterans Affairs (grant no. IK6 BX005649).

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA

    Alyssa H. Hasty

  2. VA Tennessee Valley Healthcare System, Nashville, TN, USA

    Alyssa H. Hasty

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  1. Alyssa H. Hasty
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Correspondence to Alyssa H. Hasty.

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Hasty, A.H. Iron at the intersection of macrophage–adipocyte interactions. Nat Metab 4, 1434–1435 (2022). https://doi.org/10.1038/s42255-022-00663-0

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