Scherer and colleagues demonstrate that manipulation of iron concentrations in the mitochondrial matrix of macrophages has profound effects on their polarization, leading to concomitant changes in adipocyte iron concentrations and, ultimately, systemic metabolic effects.
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A.H.H. is supported the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. DK121520) and by a Career Scientist Award from the Veterans Affairs (grant no. IK6 BX005649).
The author declares no competing interests.
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Hasty, A.H. Iron at the intersection of macrophage–adipocyte interactions. Nat Metab 4, 1434–1435 (2022). https://doi.org/10.1038/s42255-022-00663-0