Scherer and colleagues demonstrate that manipulation of iron concentrations in the mitochondrial matrix of macrophages has profound effects on their polarization, leading to concomitant changes in adipocyte iron concentrations and, ultimately, systemic metabolic effects.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Simcox, J. A. & McClain, D. A. Cell Metab. 17, 329–341 (2013).
Winn, N. C., Volk, K. M. & Hasty, A. H. JCI Insight 5, e132964 (2020).
Joffin, N. & Scherer, P. E. https://doi.org/10.1038/s42255-022-00664-z (2022).
Kratz, M. et al. Cell Metab. 20, 614–625 (2014).
Gabrielsen, J. S. et al. J. Clin. Invest. 122, 3529–3540 (2012).
Yan, H. F., Liu, Z. Y., Guan, Z. A. & Guo, C. Endocr. Connect 7, 604–616 (2018).
Fernandez-Real, J. M., Lopez-Bermejo, A. & Ricart, W. Diabetes 51, 2348–2354 (2002).
Ma, X. et al. PLoS ONE 12, e0179889 (2017).
Zhang, Z. et al. Cell Metab. 33, 1624–1639 (2021).
Kusminski, C. M. et al. Diabetes 69, 313–330 (2020).
Winn, N. C. et al. Am. J. Physiol.-Endoc. Metab. 321, E376–E391 (2021).
Orr, J. S. et al. Diabetes 63, 421–432 (2014).
Hubler, M. J., Erikson, K. M., Kennedy, A. J. & Hasty, A. H. Am. J. Physiol.-Cell. Physiol. 315, C319–C329 (2018).
Ameka, M. K. et al. Int. J. Mol. Sci. 23, 7417 (2022).
A.H.H. is supported the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. DK121520) and by a Career Scientist Award from the Veterans Affairs (grant no. IK6 BX005649).
The author declares no competing interests.
About this article
Cite this article
Hasty, A.H. Iron at the intersection of macrophage–adipocyte interactions. Nat Metab 4, 1434–1435 (2022). https://doi.org/10.1038/s42255-022-00663-0