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Liver cancer metabolism: a hexokinase from the stars

Hepatocellular carcinoma (HCC) is the 4th leading cause of cancer mortality. Modulation of tumour metabolism may represent a novel therapeutic strategy. Hexokinase 1, secreted into extracellular vesicles by activated hepatic stellate cells, is shown to be taken up by tumour cells, where it accelerates glycolysis and HCC growth.

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Fig. 1: HK1 transfer from HSCs to HCC boost glycolysis and tumour growth.


  1. Llovet, J. M. et al. Nat. Rev. Dis. Primers 7, 6 (2021).

    Article  Google Scholar 

  2. Younossi, Z. M. & Henry, L. JHEP Rep 3, 100305 (2021).

    Article  Google Scholar 

  3. Llovet, J. M. et al. Nat. Rev. Clin. Oncol. 19, 151–172 (2022).

    Article  CAS  Google Scholar 

  4. Satriano, L., Lewinska, M., Rodrigues, P. M., Banales, J. M. & Andersen, J. B. Nat. Rev. Gastroenterol. Hepatol. 16, 748–766 (2019).

    Article  CAS  Google Scholar 

  5. Wilson, J. E. J. Exp. Biol. 206, 2049–2057 (2003).

    Article  CAS  Google Scholar 

  6. Ciscato, F., Ferrone, L., Masgras, I., Laquatra, C. & Rasola, A. Int. J. Mol. Sci. 22, 4716 (2021).

    Article  CAS  Google Scholar 

  7. DeWaal, D. et al. Nat. Commun. 9, 446 (2018).

    Article  Google Scholar 

  8. Xu, S. et al. Cancer Metab. 6, 7 (2018).

    Article  Google Scholar 

  9. Chen, Q. T. et al. Nat. Metab. (2022).

  10. Mederacke, I. et al. Nat. Commun. 4, 2823 (2013).

    Article  Google Scholar 

  11. Bian, X. L. et al. Nat. Commun. 8, 14420 (2017).

    Article  CAS  Google Scholar 

  12. Lujambio, A. et al. Cell 153, 449–460 (2013).

    Article  CAS  Google Scholar 

  13. Duran, A. et al. Cancer Cell 30, 595–609 (2016).

    Article  CAS  Google Scholar 

  14. Perrin-Cocon, L. et al. Commun. Biol. 4, 217 (2021).

    Article  CAS  Google Scholar 

  15. Lawitz, E. J. et al. Hepatology 75, 912–923 (2022).

    Article  CAS  Google Scholar 

Download references


RFS is supported by NIH grants 5R01CA262424-02 and 1R01CA262424-01.

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Correspondence to Robert F. Schwabe.

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Filliol, A., Schwabe, R.F. Liver cancer metabolism: a hexokinase from the stars. Nat Metab 4, 1225–1226 (2022).

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