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Microbiome and metabolism

A gut bacterium tackles atherosclerosis

Gut commensal bacteria and their metabolites can contribute to metabolic diseases. Qiao, Liu et al. reveal that expansion of Parabacteroides merdae attenuates experimental atherosclerosis.

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Fig. 1: A synthetic ganoderma-meroterpene derivative (GMD) ameliorates experimental atherosclerosis by modulating gut microbial metabolism.


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This work was supported by the excellence initiative VASCage (Centre for Promoting Vascular Health in the Ageing Community), an R&D K-Centre (COMET program — Competence Centers for Excellent Technologies) funded by the Austrian Ministry for Transport, Innovation and Technology, the Austrian Ministry for Digital and Economic Affairs and the federal states of Tyrol, Salzburg and Vienna. T.E.A. is grateful for support from the Austrian Science Fund (FWF P33070) and the European Research Council (ERC STG 101039320).

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Correspondence to Herbert Tilg.

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Tilg, H., Adolph, T.E. A gut bacterium tackles atherosclerosis. Nat Metab 4, 1221–1222 (2022).

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