Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MICROBIOTA METABOLISM

Gut reaction: it’s not all about enzymes

Biotransformation of xenobiotics by gut microbiota can impact bioactivity and toxicity. A new study shows how hydrogen sulfide generated by gut microbes reduces azo compounds extracellularly and non-enzymatically.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Non-enzymatic reduction of azo compounds as an additional mode of microbiota–xenobiotic interactions.

References

  1. Fan, Y. & Pedersen, O. Nat. Rev. Microbiol. 19, 55–71 (2021).

    Article  CAS  Google Scholar 

  2. Gurung, M. et al. Ebiomedicine 51, 102590 (2020).

    Article  Google Scholar 

  3. Zheng, D., Liwinski, T. & Elinav, E. Cell Res. 30, 492–506 (2020).

    Article  Google Scholar 

  4. Morais, L. H., Schreiber, H. L. IV & Mazmanian, S. K. Nat. Rev. Microbiol. 19, 241–255 (2021).

    Article  CAS  Google Scholar 

  5. Lindell, A. E., Zimmermann-Kogadeeva, M. & Patil, K. R. Nat. Rev. Microbiol. 20, 431–443 (2022).

    Article  CAS  Google Scholar 

  6. Maier, L. et al. Nature 555, 623–628 (2018).

    Article  CAS  Google Scholar 

  7. Klunemann, M. et al. Nature 597, 533–538 (2021).

    Article  Google Scholar 

  8. Koppel, N., Rekdal, V. M. & Balskus, E. P. Science 356, eaag2770 (2017).

    Article  Google Scholar 

  9. Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R. & Goodman, A. L. Nature 570, 462–467 (2019).

    Article  CAS  Google Scholar 

  10. Wolfson, X. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00656-z (2022).

  11. Bakshi, H. A. et al. Pharm. 14, 1211 (2021).

    CAS  Google Scholar 

  12. Braccia, D. J., Jiang, X. F., Pop, M. & Hall, A. B. Front Microbiol 12, 705583 (2021).

    Article  Google Scholar 

  13. Lee, J. Y., Tsolis, R. M. & Baumler, A. J. Science 377, eabp9960 (2022).

    Article  CAS  Google Scholar 

  14. Han, S. et al. Nature 595, 415–420 (2021).

    Article  CAS  Google Scholar 

  15. van der Zee, F. P. et al. Water Res. 37, 3098–3109 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kiran R. Patil.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kamrad, S., Lindell, A.E. & Patil, K.R. Gut reaction: it’s not all about enzymes. Nat Metab 4, 1219–1220 (2022). https://doi.org/10.1038/s42255-022-00637-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-022-00637-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing