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A stochastic basis for metabolic phenotypes

Nature Metabolism volume 4, pages 1091–1092 (2022)Cite this article

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It has long been recognized that some phenotypic variation in mammals cannot be explained by known genetic or environmental variables. Here, the authors show that the absence of Nnat expression is associated with polyphenism in mice with the same genotype. Broadly consistent effects are also found in humans.

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Fig. 1: A mouse model for understanding the origins of unexplained phenotypic variation.

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Authors and Affiliations

  1. Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King’s College London, London, UK

    Michelle L. Holland

  2. The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Vardhman K. Rakyan

Authors
  1. Michelle L. Holland
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  2. Vardhman K. Rakyan
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Corresponding authors

Correspondence to Michelle L. Holland or Vardhman K. Rakyan.

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The authors declare no competing interests.

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Holland, M.L., Rakyan, V.K. A stochastic basis for metabolic phenotypes. Nat Metab 4, 1091–1092 (2022). https://doi.org/10.1038/s42255-022-00630-9

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