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Who knew? PPARs may act in the brain too

New research shows that a drug conjugate that links the dual PPAR𝛼/𝛾 agonist tesaglitazar to a GLP-1 receptor agonist has superior effects on weight loss and glucose metabolism compared with monotherapy in mice. The conjugate has actions in the hypothalamus that may contribute to its benefits.

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Fig. 1: Conjugates for the treatment of metabolic disease.


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Correspondence to Randy J. Seeley.

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Competing interests

R.J.S. receives research support from AstraZeneca, Novo Nordisk and Fractyl. R.J.S. has served as a paid consultant for Novo Nordisk, Scohia, CinRx, ShouTi Pharma and Fractyl. R.J.S. has equity in Calibrate and Rewind. This work was supported by NIH grants to R.J.S. P01DK117821 and P30DK089503. C.J.R. is an employee of AstraZeneca and owns AstraZeneca stock.

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Seeley, R.J., Rhodes, C.J. Who knew? PPARs may act in the brain too. Nat Metab 4, 965–966 (2022).

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