Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Prolonged lactation benefits offspring metabolism

Longer duration of breastfeeding is shown to have long-lasting effects in rodents, which lead to an adult phenotype that is resistant to diet-induced obesity and has increased brown adipose tissue activity through a process dependent on hypothalamic FGF21 signalling.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Effects of prolonged lactation.


  1. Kusuyama, J., Alves-Wagner, A. B., Makarewicz, N. S. & Goodyear, L. J. Nat. Metab. 2, 858–872 (2020).

    Article  Google Scholar 

  2. Kereliuk, S. M., Brawerman, G. M. & Dolinsky, V. W. Int. J. Mol. Sci. 18, 1451 (2017).

    Article  Google Scholar 

  3. Dearden, L. & Ozanne, S. E. Front. Neuroendocrinol. 39, 3–16 (2015).

    Article  Google Scholar 

  4. Pena-León, V. et al. Nat. Metab. (2022).

    Article  Google Scholar 

  5. Waddington, C. H. The Epigenotpye. Endeavour 1, 18–20 (1942).

    Google Scholar 

  6. Lin, X. H. et al. Sci. Rep. 11, 316 (2021).

    Article  CAS  Google Scholar 

  7. Kusuyama, J. et al. Cell Metab. 33, 939–956.e8 (2021).

    Article  CAS  Google Scholar 

  8. Han, L. et al. Nat. Genet. 50, 432–442 (2018).

    Article  CAS  Google Scholar 

  9. Gu, T. P. et al. Nature 477, 606–610 (2011).

    Article  CAS  Google Scholar 

  10. Hondares, E. et al. Cell Metab. 11, 206–212 (2010).

    Article  CAS  Google Scholar 

  11. Flippo, K. H. & Potthoff, M. J. Nat. Metab. 3, 309–317 (2021).

    Article  CAS  Google Scholar 

  12. Folgueira, C. et al. Nat. Metab. 1, 811–829 (2019).

    Article  CAS  Google Scholar 

  13. Cheshmeh, S., Nachvak, S. M., Rezvani, N. & Saber, A. Diabetes Metab. Syndr. Obes. 13, 2227–2237 (2020).

    Article  CAS  Google Scholar 

  14. Becher, T. et al. Nat. Med. 27, 58–65 (2021).

    Article  CAS  Google Scholar 

  15. Carpentier, A. C. et al. Front. Endocrinol. 9, 447 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kristin I. Stanford.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Félix-Soriano, E., Stanford, K.I. Prolonged lactation benefits offspring metabolism. Nat Metab 4, 798–799 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing