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ENDOTHELIAL METABOLISM

YAP/TAZ–TEAD link angiogenesis to nutrients

Nature Metabolism volume 4, pages 645–646 (2022)Cite this article

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Ong et al. uncover a role for the YAP/TAZ–TEAD transcriptional pathways in retinal angiogenesis via the regulation of amino acid transporters and assessed mTORC activation. These findings establish the mechanism through which endothelial cells regulate nutrient acquisition and consumption.

Endothelial cells (ECs) form a dense network of blood vessels that branch out along the entire body carrying oxygen, macromolecules and nutrients to all tissues and organs1,2. ECs are exposed to diverse types of nutrients such as sugars, amino acids and various lipids. It is conceivable that during vascular growth, ECs increase nutrient uptake and usage to meet the metabolic needs of the angiogenic process. Accordingly, ECs must be equipped with specific mechanisms that help in this process and fuel perivascular tissues3,4,5. How ECs controls nutrient acquisition and utilization is still poorly understood.

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Fig. 1: YAP/TAZ–TEAD pathway supports retinal angiogenesis by controlling nutrient transporter levels and mTORC1 activation.

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  1. Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy

    Roxana E. Oberkersch & Massimo M. Santoro

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  1. Roxana E. Oberkersch
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  2. Massimo M. Santoro
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Correspondence to Massimo M. Santoro.

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Oberkersch, R.E., Santoro, M.M. YAP/TAZ–TEAD link angiogenesis to nutrients. Nat Metab 4, 645–646 (2022). https://doi.org/10.1038/s42255-022-00579-9

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