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YAP/TAZ–TEAD link angiogenesis to nutrients

Ong et al. uncover a role for the YAP/TAZ–TEAD transcriptional pathways in retinal angiogenesis via the regulation of amino acid transporters and assessed mTORC activation. These findings establish the mechanism through which endothelial cells regulate nutrient acquisition and consumption.

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Fig. 1: YAP/TAZ–TEAD pathway supports retinal angiogenesis by controlling nutrient transporter levels and mTORC1 activation.


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Correspondence to Massimo M. Santoro.

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Oberkersch, R.E., Santoro, M.M. YAP/TAZ–TEAD link angiogenesis to nutrients. Nat Metab 4, 645–646 (2022).

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