Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


TKT deficiency puts Tregs to rest

Activation of resting regulatory T cells (Tregs) upon antigen encounter is essential for proper Treg function. However, the metabolic pathways that mediate this transition are unknown. Liu et al. have identified the non-oxidative pentose phosphate pathway as a central regulator of Treg activation and function.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Transketolase (TKT) deficiency impairs the activation and function of regulatory T cells (Tregs).


  1. Michalek, R. D. et al. J. Immunol. 186, 3299–3303 (2011).

    Article  CAS  Google Scholar 

  2. Procaccini, C. et al. Immunity 44, 406–421 (2016).

    Article  CAS  Google Scholar 

  3. Soto-Heredero, G., Gómez de Las Heras, M. M., Gabandé-Rodríguez, E., Oller, J. & Mittelbrunn, M. FEBS J. 287, 3350–3369 (2020).

    Article  CAS  Google Scholar 

  4. Baardman, J. et al. Cell Rep. 25, 2044–2052.e5 (2018).

    Article  CAS  Google Scholar 

  5. Britt, E. C. et al. Nat. Metab. 4, 389–403 (2022).

    Article  Google Scholar 

  6. Liu, Q. et al. Nat. Metab. (2022).

    Article  PubMed  Google Scholar 

  7. Skartsis, N. et al. Front. Immunol. 12, 783282 (2021).

    Article  CAS  Google Scholar 

  8. Mottet, C., Uhlig, H. H. & Powrie, F. J. Immunol. 170, 3939–3943 (2003).

    Article  CAS  Google Scholar 

  9. Ren, J. et al. PLoS Biol. 17, e3000270 (2019).

    Article  CAS  Google Scholar 

  10. Martínez-Reyes, I. & Chandel, N. S. Nat. Commun. 11, 102 (2020).

    Article  Google Scholar 

  11. Xiao, M. et al. Genes Dev. 26, 1326–1338 (2012).

    Article  CAS  Google Scholar 

  12. Patra, K. C. & Hay, N. Trends Biochem. Sci. 39, 347–354 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Margarita Dominguez-Villar.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dominguez-Villar, M. TKT deficiency puts Tregs to rest. Nat Metab 4, 503–504 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing