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IMMUNOMETABOLISM

TKT deficiency puts Tregs to rest

Activation of resting regulatory T cells (Tregs) upon antigen encounter is essential for proper Treg function. However, the metabolic pathways that mediate this transition are unknown. Liu et al. have identified the non-oxidative pentose phosphate pathway as a central regulator of Treg activation and function.

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Fig. 1: Transketolase (TKT) deficiency impairs the activation and function of regulatory T cells (Tregs).

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Correspondence to Margarita Dominguez-Villar.

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Dominguez-Villar, M. TKT deficiency puts Tregs to rest. Nat Metab 4, 503–504 (2022). https://doi.org/10.1038/s42255-022-00574-0

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