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Peeling back the layers of the glucose clamp

Nature Metabolism volume 4, pages 496–498 (2022)Cite this article

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Glucose clamps are challenging to conduct in mice and experimental approaches vary between laboratories, which complicates data interpretation and comparison of results. Here, we highlight key methodological differences and propose reporting standards for glucose clamps.

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Acknowledgements

The authors receive support from the Vanderbilt Mouse Metabolic Phenotyping Center (NIH DK059637) and the Vanderbilt Diabetes Research Center (NIH DK020593).

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Authors and Affiliations

  1. Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, TN, USA

    Julio E. Ayala, Louise Lantier, Owen P. McGuinness & David H. Wasserman

  2. Vanderbilt Diabetes Research Center, Vanderbilt University, Nashville, TN, USA

    Julio E. Ayala, Louise Lantier, Owen P. McGuinness & David H. Wasserman

  3. Mouse Diabetes Clinic at Vanderbilt, Vanderbilt University, Nashville, TN, USA

    Julio E. Ayala, Louise Lantier, Owen P. McGuinness & David H. Wasserman

  4. Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA

    Julio E. Ayala, Louise Lantier, Owen P. McGuinness & David H. Wasserman

Authors
  1. Julio E. Ayala
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  2. Louise Lantier
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  3. Owen P. McGuinness
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  4. David H. Wasserman
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Contributions

J.E.A., L.L., O.P.M. and D.H.W. contributed to writing the first draft and subsequent edits of this Comment.

Corresponding author

Correspondence to David H. Wasserman.

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The authors declare no competing interests.

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Ayala, J.E., Lantier, L., McGuinness, O.P. et al. Peeling back the layers of the glucose clamp. Nat Metab 4, 496–498 (2022). https://doi.org/10.1038/s42255-022-00573-1

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