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Astroglial clean-up of satiety synapses

Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

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Fig. 1: Astrocytes govern excitatory neurotransmission and feeding behaviour by integrating BDNF–TrkB.T1 signalling.


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The authors thank C. Holleman for her comments. The authors’ research is supported by funding from the European Research Council ERC (CGC: STG grant AstroNeuroCrosstalk # 757393), the German Research Foundation DFG under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198) and Helmholtz Excellence Network and the Deutsche Forschungsgemeinschaft (GS: SPP1757 - SA2114/2-2), and Helmholtz Association – Initiative and Networking Fund. The funders had no role in the decision to publish or prepare this work.

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Correspondence to Cristina García-Cáceres.

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Gruber, T., García-Cáceres, C. Astroglial clean-up of satiety synapses. Nat Metab 4, 505–506 (2022).

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